Cobamamide was discovered by American scientists Baker and others in 1958. Since then, scholars around the world have carried out extensive research on its biochemical properties and pharmacological mechanism of action. Pharmacological and biological effects of Cobamamide have been discovered successively. Cobamamide is essential for cell growth and reproduction and for maintaining the integrity of nerve myelin. At present, it has been widely used in clinical treatment in Europe, America, Japan and other developed countries with satisfying results. It is suitable for megaloblastic anemia, nutritional anemia, pregnancy anemia, polyneuritis, radiculitis, trigeminal neuralgia, sciatica, nerve paralysis. It can also be used as an adjunctive treatment for nutritional disorders and leukopenia induced by radiation and drugs.